​The cast features ​Mark Bellemare (Calvin/Reader 11), Cian Evans-Grayson (Meg Murry), Cate Heybrock (Aunt Beast/Reader 8), Jordyn Jenkins (Mrs. Murray/Reader 9), Bella Kelso (Mrs. Who/Reader 3), Veronique Le (Mrs. Whatsit/Reader 5), Brady Magruder (Mr. Murray/Reader 2), Josh Nett (Charles Wallace/Reader 7), Kelly Simmons (Mrs. Which/Reader 12), Hallie Snowday (Happy Medium/Reader 1), Daniel Suarez Velez (Sandy/Reader 6/Charles Wallace Puppet), Danny Tramontana (Man with Red Eyes/Fortinbras/Reader 4), and Thomas B. Tran (Dennys/Paperboy/Reader 10).

The production team includes scenic design by Caitlyn Girten, costume design by Joeffrey Wenderlich, wig & makeup design by Hannah Andruss, lighting design by Ellie Fey, composition and sound design by Ethan Korvne, projection design by Dwight Bellisimo, technical direction by Sara Johnson, dramaturgy by LeeAnne Nakamura & Joan Starkey, production stage management by Rachel Silver, and stage management by Alix MacDonald.